연구 및 학술활동

Correlation between breast arterial calcification detected on mammography and cerebral artery disease

Kook Jin Ahn • Young Joo Kim • Hang Joo Cho • Hyeon Woo Yim •

Bong Joo Kang • Sung Hun Kim • Hyun Suk Kim • Ki Tae Kim •

Jae Hee Lee • In Yong Whang



K. J. Ahn  Y. J. Kim  B. J. Kang  S. H. Kim  H. S. Kim  K. T. Kim  I. Y. Whang (&)

Department of Radiology, College of Medicine,

Uijeongbu St. Mary’s Hospital, The Catholic University

of Korea, CPO Box, Kyunggido 480-717, Korea

e-mail: tiger@catholic.ac.kr

H. J. Cho

Department of Surgery, College of Medicine,

The Catholic University of Korea, Kyunggido, Korea

H. W. Yim

The Clinical Research Coordinating Center,

College of Medicine, The Catholic University of Korea,

Seoul, Korea

J. H. Lee

Human Medical Imaging and Intervention Center, Seoul, Korea



Arch Gynecol Obstet

DOI 10.1007/s00404-010-1742-4





Abstract

Purpose This study was carried out to determine the relationship between breast arterial calcification (BAC) and cerebral artery disease.

Materials and methods We investigated the relationship between BAC on mammography and cerebral artery-origin T2-hyperintensity on brain MRI and which is associated with an increased risk for stroke. A total of 168 women, ages 40–78 years, who underwent both mammography and brain MRI, were enrolled in this study. BAC was counted as positive if it was found on more than one view a breast.

The T2-hyperintensity was systemically defined and graded as follows: punctuate; patchy; and confluent white-matter hyperintensity (WMH); caps; bands; and irregular periventricular hyperintensity (PVH). Patchy and confluent WMH and irregular PVH were considered as positive findings for cerebral artery disease. We also obtained data regarding cardiovascular risk factors that might function as confounding factors. Statistical analysis was performed for association of the BAC and positive MRI findings.

Result The presence of BAC showed a strong correlation with the positive MRI findings (Odds ratios, adjusted with statically significant cardiovascular factors of 6.86 for positive WMH and 9.04 for positive PVH, p.05).

Conclusion The mammographic finding of BAC, which may be a useful marker of women at higher risk for stroke, should receive more of clinicians’ attention and its presence should never be omitted from the report.

Keywords Breast arterial calcification  Breast 

Mammography  Cerebral artery disease  Leukoaraiosis 

Magnetic resonance (MR)



유방촬영술에서 보이는 혈관석회가 뇌MRI 검사의 이상소견과 강한 연관관계가 있으니 혈관석회에 대해서 판독지에 언급해주는 것이 좋겠다는 내용의 초록임.



작성자: 유방클리닉 원장 이재희